2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-126996
    Triiodothyronine sulfate
    		≥98.0%
    Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.
    Triiodothyronine sulfate
  • HY-135335S
    3'-Hydroxy Repaglinide-d5
    		≥98.0%
    3'-Hydroxy Repaglinide-d5 is the deuterium labeled 3'-Hydroxy Repaglinide. 3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide[1].
    3'-Hydroxy Repaglinide-d<sub>5</sub>
  • HY-126303
    GS-443902
    		99.87%
    GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir.
    GS-443902
  • HY-117433S
    4-Hydroperoxy Cyclophosphamide-d4
    4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].
    4-Hydroperoxy Cyclophosphamide-d<sub>4</sub>
  • HY-B0199S
    Mycophenolate Mofetil-d4
    		99.47%
    Mycophenolate Mofetil-d4 is the deuterium labeled Mycophenolate Mofetil. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation[1].
    Mycophenolate Mofetil-d<sub>4</sub>
  • HY-135391S
    Ezetimibe phenoxy glucuronide-d4
    Ezetimibe phenoxy glucuronide-d4 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].
    Ezetimibe phenoxy glucuronide-d<sub>4</sub>
  • HY-131267
    Febuxostat sec-butoxy acid
    Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat sec-butoxy acid
  • HY-W012982S
    3-Amino-2-oxazolidinone-d4
    		≥99.0%
    3-Amino-2-oxazolidinone-d4 is a deuterium labeled 3-Amino-2-oxazolidinone. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as an indicator of furazolidone residues[1][2].
    3-Amino-2-oxazolidinone-d<sub>4</sub>
  • HY-B2124
    10,11-Dihydrocarbamazepine
    10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy.
    10,11-Dihydrocarbamazepine
  • HY-133770
    Seco Rapamycin ethyl ester
    Seco Rapamycin ethyl ester is an open-ring metabolite of Rapamycin derivative. Seco-rapamycin is reported not to affect the mTOR function.
    Seco Rapamycin ethyl ester
  • HY-113095
    γ-CEHC
    		98.3%
    γ-CEHC is a γ-tocopherol (HY-N7148) metabolite. γ-CEHC is mainly excreted into the urine rather than into the bile. γ-CEHC is present in conjugated form in human urine, mainly as glucuronide.
    γ-CEHC
  • HY-113456S
    Leukotriene D4-d5
    		≥98.0%
    Leukotriene D4-d5 is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.
    Leukotriene D4-d<sub>5</sub>
  • HY-G0002A
    Lurasidone metabolite 14326 hydrochloride
    		Chemical 99.42%
    Lurasidone metabolite 14326 (hydrochloride) is an active metabolite of the atypical antipsychotic Lurasidone.
    Lurasidone metabolite 14326 hydrochloride
  • HY-B0601
    Tafluprost acid
    		Chemical 99.80%
    Tafluprost acid (AFP-172), an active metabolic form of Tafluprost, is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor. Tafluprost acid can be used in the research of glaucoma.
    Tafluprost acid
  • HY-12778S
    N-Demethyl Ivabradine-d6 hydrochloride
    		≥98.0%
    N-Demethyl Ivabradine-d6 (hydrochloride) is the deuterium labeled N-Demethyl Ivabradine, which is a metabolite of Ivabradine.
    N-Demethyl Ivabradine-d<sub>6</sub> hydrochloride
  • HY-122439
    Lovastatin acid
    Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM.
    Lovastatin acid
  • HY-103687
    Abiraterone metabolite 1
    		99.59%
    Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone. Abiraterone, a steroidal agent, inhibits CYP17A1, blocks androgen synthesis and prolongs survival in prostate cancer.
    Abiraterone metabolite 1
  • HY-100646AS
    (Z)-10-Hydroxynortriptyline-d3
    		≥99.0%
    (Z)-10-Hydroxynortriptyline-d3 is the deuterium labeled (Z)-10-Hydroxynortriptyline (HY-100646A). (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1][2].
    (Z)-10-Hydroxynortriptyline-d<sub>3</sub>
  • HY-12769
    Mebeverine acid
    		99.70%
    Mebeverine acid (Mebeverine metabolite Mebeverine acid) is a secondary metabolite of Mebeverine. Mebeverine is an antispasmodic agent. Mebeverine acid is a valuable marker of oral exposure to Mebeverine.
    Mebeverine acid
  • HY-136611
    ω-Hydroxy-DEET
    		98.60%
    ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes.
    ω-Hydroxy-DEET
Cat. No. Product Name / Synonyms Application Reactivity